Immunomodulatory effects of diet and nutrients in systemic lupus erythematosus (SLE): A systematic review
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Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MalaysiaIssue Date
2020-07-22
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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.Citation
Islam MA, Khandker SS, Kotyla PJ and Hassan R (2020) Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review. Front. Immunol. 11:1477. doi: 10.3389/fimmu.2020.01477Publisher
Frontiers Media SAJournal
Frontiers in ImmunologyPubMed ID
32793202 (pubmed)Additional Links
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01477/fullType
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enDescription
© 2020 The Authors. Published by Frontiers SA. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3389/fimmu.2020.01477ISSN
1664-3224EISSN
1664-3224Sponsors
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2020.01477
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Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International
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