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dc.contributor.authorNair, Manisha
dc.contributor.authorChurchill, David
dc.contributor.authorNelson-Piercy, Cathy
dc.contributor.authorStanworth, Simon J
dc.contributor.authorKnight, Marian
dc.date.accessioned2023-03-21T10:42:31Z
dc.date.available2023-03-21T10:42:31Z
dc.date.issued2017-03-28
dc.identifier.citationNair, M., Churchill, D., Nelson-Piercy, C., Stanworth, S.J. and Knight, M. (2017) Association between maternal haemoglobin concentration and stillbirth: A cohort study among a multi-ethnic population in England. BJOG: An International Journal of Obstetrics and Gynaecology, 124(S2), P.PO.65en
dc.identifier.issn1470-0328en
dc.identifier.urihttp://hdl.handle.net/2436/625152
dc.descriptionThis is an accepted manuscript of an article published by Wiley on 28/03/2017, in the Special Issue: Abstracts of the British Maternal & Fetal Medicine Society (BMFMS) 19th Annual Conference 2017. 30–31 March 2017, Amsterdam, The Netherlands, available online: https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.14589 The accepted version of the publication may differ from the final published version.en
dc.description.abstractIntroduction There have been many calls for action to reduce stillbirths including the need to understand the determinants. Low maternal haemoglobin concentrations have been explored as a risk factor for stillbirth and perinatal death, but evidence is weak. The objective of this work was to examine the association of maternal haemoglobin concentration with stillbirth and perinatal death in a multi-ethnic population in England. Methods A retrospective cohort analysis was conducted using anonymised data from 14 001 women with singleton pregnancies ≥24 weeks of gestation giving birth in two hospitals in 2013–15. Multivariable logistic regression models were built to analyse associations between maternal haemoglobin at first visit and at 28 weeks with stillbirth and perinatal death, adjusting for 11 other risk factors. Results Almost half of the study population had anaemia at some point during their pregnancy. The risk of stillbirth and perinatal death decreased linearly per unit increase in haemoglobin concentration at first visit (adjusted odds ratio [aOR] stillbirth = 0.70, 95% CI 0.58–0.85; aOR perinatal death = 0.71, 95% CI 0.60–0.84) and at 28 weeks (aOR stillbirth = 0.83, 95% CI 0.62–1.11; aOR perinatal death = 0.86, 95% CI 0.67–1.12). Compared with women with normal haemoglobin concentrations, the risk of stillbirth and perinatal death was five-fold and three-fold higher in women with moderate-severe maternal anaemia at first visit and 28 weeks, respectively. Conclusion These findings are of clinical and public health importance. If the observed association is causal, iron supplementation during pregnancy could have an incremental benefit on reducing the risk of stillbirth and perinatal death for all women.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttps://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.14589en
dc.subjecthaemoglobin concentrationen
dc.subjectpregnancyen
dc.subjectstillbirthen
dc.subjectperinatal deathen
dc.subjectmaternal anaemiaen
dc.titleAssociation between maternal haemoglobin concentration and stillbirth: A cohort study among a multi-ethnic population in Englanden
dc.typeConference contributionen
dc.identifier.eissn1471-0528
dc.identifier.journalBJOG: An International Journal of Obstetrics and Gynaecologyen
dc.date.updated2023-03-17T17:04:12Z
dc.conference.nameBritish Maternal & Fetal Medicine Society (BMFMS) 19th Annual Conference 2017
dc.conference.locationAmsterdam, Netherlands
pubs.finish-date2017-03-31
pubs.start-date2017-03-30
dc.date.accepted2017-03-17
rioxxterms.funderRoyal Wolverhampton Hospitals NHS Trusten
rioxxterms.identifier.projectUOW21032023DCen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2023-03-21en
dc.source.volume124
dc.source.beginpage143
dc.source.endpage143
dc.description.versionPublished version
refterms.dateFCD2023-03-21T10:42:05Z
refterms.versionFCDAM
refterms.dateFOA2023-03-21T10:42:31Z


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